Global mean atmospheric carbon dioxide (CO2) concentration has now passed 400 ppm, a level that last occurred about 3 million years ago, when global average temperature and sea level were significantly higher than today (high confidence). Continued growth in CO2 emissions over this century and beyond would lead to an atmospheric concentration not experienced in tens of millions of years (medium confidence). The present-day emissions rate of nearly 10 GtC per year suggests that there is no climate analog for this century any time in at least the last 50 million years (medium confidence).